(S)-(+)-2-(苯胺基甲基)吡咯烷合成路线 （共 18 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-15 - 65°C; 7 h;
参考文献
Dunina, Valery V.; Gorunova, Olga N.; Stepanova, Valeriya A.; Zykov, Pavel A.; Livantsov, Michail V.; Grishin, Yuri K.; Churakov, Andrey V.; Kuz'mina, Lyudmila G.
Tetrahedron Asymmetry, 2007 , vol. 18, # 17 p. 2011 - 2015
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction;
参考文献
Brunel, Jean Michel; Constantieux, Thierry; Buono, Gerard
Journal of Organic Chemistry, 1999 , vol. 64, # 24 p. 8940 - 8942
反应条件
1: 95 percent / CH2Cl2 / 2.5 h / 0 °C 2: ethyl chloroformate; 4-methylmorpholine / 0.17 h / 0 °C 3: CH2Cl2 / 13 h / 0 - 20 °C 4: 83 percent / trifluoroacetic acid / CH2Cl2 / 4 h / 20 °C 5: 83 percent / LiAlH4 / tetrahydrofuran / 7 h / -15 - 65 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2011 - 2015
反应条件
1: 90 percent / H2 / 10percent Pd/C / methanol / 5 h / Ambient temperature 2: 78 percent / LiAlH4 / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2117 - 2127
反应条件
1: 1.) N-methylmorpholine, EtOCOCl 2: 90 percent / H2 / 10percent Pd/C / methanol / 5 h / Ambient temperature 3: 78 percent / LiAlH4 / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2117 - 2127
反应条件
1: 47 percent / 0.67 h / 195 - 200 °C 2: 75 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 3 p. 444 - 454
反应条件
1: 85 percent / 4 h / 195 - 200 °C 2: 92 percent / LiAlH4 / tetrahydrofuran View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 24 p. 8940 - 8942
反应条件
hydrogenchloride 1.)-100 deg C 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Sakito, Yoji; Suzukamo, Gohfu
Tetrahedron Letters, 1982 , vol. 23, # 47 p. 4953 - 4954
反应条件
1: ethyl chloroformate; 4-methylmorpholine / 0.17 h / 0 °C 2: CH2Cl2 / 13 h / 0 - 20 °C 3: 83 percent / trifluoroacetic acid / CH2Cl2 / 4 h / 20 °C 4: 83 percent / LiAlH4 / tetrahydrofuran / 7 h / -15 - 65 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2011 - 2015
反应条件
1: CH2Cl2 / 13 h / 0 - 20 °C 2: 83 percent / trifluoroacetic acid / CH2Cl2 / 4 h / 20 °C 3: 83 percent / LiAlH4 / tetrahydrofuran / 7 h / -15 - 65 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2011 - 2015
