(S)-(+)-2-(苯胺基甲基)吡咯烷合成路线 (共 18 条)
反应条件
1: 83 percent / trifluoroacetic acid / CH2Cl2 / 4 h / 20 °C 2: 83 percent / LiAlH4 / tetrahydrofuran / 7 h / -15 - 65 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2011 - 2015
反应条件
1: 95.4 percent / toluene / 2 h / Heating 2: 44.7 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 14 p. 1735 - 1741
反应条件
1: -100 °C 2: 2.) 2percent hydrochoric acid / 1.)-100 deg C 2.) 0 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 23, # 47 p. 4953 - 4954
反应条件
lithium aluminium tetrahydride 1.) 195 deg C, 4 h; 2.) THF, 0 deg C; Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 40, # 18 p. 3561 - 3564
反应条件
hydrogenchloride 1.)-100 deg C 2.) 0 deg C; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 23, # 47 p. 4953 - 4954
反应条件
hydrogenchloride; lithium diisopropyl amide 1) THF, -78 deg C; 2) r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemistry Letters, , p. 455 - 458
反应条件
hydrogenchloride; zinc 1) benzene, reflux; 2) r.t., 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemistry Letters, , p. 455 - 458
反应条件
lithium aluminium tetrahydride 1.) ether, r. t., 30 min, 2.) toluene, r. t., 4 d; Multistep reaction;
参考文献
MacPherson, Andrew J.; Smith, David J. H.
Journal of Chemical Research, Miniprint, 1984 , # 2 p. 315 - 345