1: With (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 24 h; 2: With trichloroacetonitrile; bis(tetra-n-butylammonium) hydrogen phosphate in acetonitrile T=20°C; 24 h;

1.1: N-ethyl-N,N-diisopropylamine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid / dichloromethane / 24 h / 20 °C 1.2: 24 h / 20 °C 2.1: Streptomyces coelicolor A3(2) 2-methylisoborneol synthase; magnesium chloride; sodium chloride; 2-hydroxyethanethiol / aq. buffer / 12 h / 30 °C / pH 7 / |Enzymatic reaction View Scheme