N-Boc-L-正亮氨酸合成路线 （共 27 条）
反应条件
1: toluene / 85 °C 2: aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 3 p. 719 - 722
反应条件
1: 50 percent / CuBr*Me2S / toluene / 4 h / -50 °C 2: trifluoroacetic acid View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 21 p. 3761 - 3764
反应条件
1: 90 percent / pyridine 2: dimethylformamide / 1 h / 0 °C 3: 92 percent / NaBH4 / methanol / 1 h / 25 °C 4: 93 percent / mCPBA / CH2Cl2 / 1 h / 25 °C 5: 95 percent / PyH*OTs / CH2Cl2 / 24 h / 25 °C 6: 1.) n-BuLi / 1.) THF, -78 deg C; 2.) -50 deg C, 2 h 7: PyH*OTS / ethanol / 6 h / 60 °C 8: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C 9: 81 percent / pyridinium dichromate / dimethylformamide / 6 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 48 p. 6069 - 6072
反应条件
1: dimethylformamide / 1 h / 0 °C 2: 92 percent / NaBH4 / methanol / 1 h / 25 °C 3: 93 percent / mCPBA / CH2Cl2 / 1 h / 25 °C 4: 95 percent / PyH*OTs / CH2Cl2 / 24 h / 25 °C 5: 1.) n-BuLi / 1.) THF, -78 deg C; 2.) -50 deg C, 2 h 6: PyH*OTS / ethanol / 6 h / 60 °C 7: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C 8: 81 percent / pyridinium dichromate / dimethylformamide / 6 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 48 p. 6069 - 6072
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C; 2.) -50 deg C, 2 h 2: PyH*OTS / ethanol / 6 h / 60 °C 3: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C 4: 81 percent / pyridinium dichromate / dimethylformamide / 6 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 48 p. 6069 - 6072
反应条件
1: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C 2: 81 percent / pyridinium dichromate / dimethylformamide / 6 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 48 p. 6069 - 6072
反应条件
1: PyH*OTS / ethanol / 6 h / 60 °C 2: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C 3: 81 percent / pyridinium dichromate / dimethylformamide / 6 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 48 p. 6069 - 6072
反应条件
triethylamine in 1,4-dioxane; water 4 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 47, # 29 p. 5453 - 5462
反应条件
sodium carbonate in water; tert-butyl alcohol
参考文献
Justus Liebigs Annalen der Chemie, , vol. 692, p. 237 - 240
反应条件
trifluoroacetic acid
参考文献
Tetrahedron Letters, , vol. 37, # 21 p. 3761 - 3764
