N-苄基-3,3'-亚氨基二丙酸合成路线 （共 3 条）
反应条件
1: 5-Nitro-1H-indole With hydrogen; palladium on activated carbon in ethyl acetate T=20°C; P=2280.15 Torr; 1.5 h; 2: N-benzyliminodiacetic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran 3 h; Heating / reflux; 3: With lithium aluminium tetrahydride; sulfuric acid; ammonium formate; palladium on activated carbon more than 3 stages;
参考文献
H. Lundbeck A/S
Patent: US2003/232822 A1, 2003 ;
Location in patent: Page 7,8 ;
反应条件
sodium hydroxide in methanol
T=65°C;
参考文献
Zahouily, Mohamed; Mounir, Bahija; Cherki, Hind; Bahlaouan, Bouchaib; Rayadh, Ahmed; Sebti, Said
Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 6 p. 1203 - 1217
反应条件
1: 95 percent / KF / natural phosphate / 1 h / Heating
2: 72 percent / NaOH / methanol / 65 °C
View Scheme
参考文献
Zahouily, Mohamed; Bahlaouan, Bouchaib; Rayadh, Ahmed; Sebti, Said
Tetrahedron Letters, 2004 , vol. 45, # 21 p. 4135 - 4138
