4-溴-6-甲氧基-2,3-二甲基-吡啶合成路线 （共 5 条）
反应条件
silver carbonate in benzene
T=45°C; 48 h;
参考文献
McElroy, William T.; DeShong, Philip
Organic Letters, 2003 , vol. 5, # 25 p. 4779 - 4782
反应条件
1: POBr3 / dimethylformamide / 0.75 h / 110 °C
2: 12.70 g / Ag2CO3 / CHCl3 / 24 h / 50 °C
View Scheme
参考文献
McElroy, William T.; DeShong, Philip
Tetrahedron, 2006 , vol. 62, # 29 p. 6945 - 6954
反应条件
1.1: NaOH / H2O / 2 h / Heating
1.2: 99 percent / HCl / H2O / 12 h / 20 °C / pH 7
2.1: POBr3 / dimethylformamide / 0.75 h / 110 °C
3.1: 12.70 g / Ag2CO3 / CHCl3 / 24 h / 50 °C
View Scheme
参考文献
McElroy, William T.; DeShong, Philip
Tetrahedron, 2006 , vol. 62, # 29 p. 6945 - 6954
反应条件
1.1: 93 percent / ammonium hydroxide; Bentonite K-10 / 24 h / 20 °C
2.1: sodium; ethanol / toluene / 1 h
2.2: 65 percent / ethanol; toluene / 96 h / Heating
3.1: NaOH / H2O / 2 h / Heating
3.2: 99 percent / aq. HCl / 0 °C / pH 7
4.1: POBr3 / dimethylformamide / 0.5 h / 110 °C
5.1: 1.64 g / Ag2CO3 / benzene / 48 h / 45 °C
View Scheme
参考文献
McElroy, William T.; DeShong, Philip
Organic Letters, 2003 , vol. 5, # 25 p. 4779 - 4782
反应条件
1.1: sodium; ethanol / toluene / 1 h
1.2: 65 percent / ethanol; toluene / 96 h / Heating
2.1: NaOH / H2O / 2 h / Heating
2.2: 99 percent / aq. HCl / 0 °C / pH 7
3.1: POBr3 / dimethylformamide / 0.5 h / 110 °C
4.1: 1.64 g / Ag2CO3 / benzene / 48 h / 45 °C
View Scheme
参考文献
McElroy, William T.; DeShong, Philip
Organic Letters, 2003 , vol. 5, # 25 p. 4779 - 4782
