4-氟-1-[三(1-甲基乙基)硅酯]-1H-吡咯并[2,3-B]吡啶合成路线 （共 12 条）
反应条件
1.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C
1.2: 30 percent / tosyl azide / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C
2.1: 100 percent / H2 / Pd/C / ethyl acetate / 18 h / 20 °C / 760.05 Torr
View Scheme
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
1-methyl-pyrrolidin-2-one; triethylamine
T=160°C; 2 h; microwave irradiation;
参考文献
Caldwell, John J.; Cheung, Kwai-Ming; Collins, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1527 - 1529
