2-苯基嘧啶-5-羧酸甲酯合成路线 （共 6 条）
反应条件
in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2007/41634 A1, 2007 ;
Location in patent: Page/Page column 34-35 ;
WO 2007/041634 A1
反应条件
in 1,4-dioxane T=22°C; Diels-Alder reaction; 0.0833333 h; regioselective reaction;
参考文献
Anderson, Erin D.; Boger, Dale L.
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 12285 - 12292
反应条件
in N,N-dimethyl-formamide T=100°C; Diels-Alder reaction; 24 h; regioselective reaction;
参考文献
Anderson, Erin D.; Boger, Dale L.
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 12285 - 12292
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: sodium periodate / dichloromethane / 2 h / 22 °C / Inert atmosphere 2.2: Inert atmosphere 3.1: 1,4-dioxane / 0.08 h / 22 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 31 p. 12285 - 12292
反应条件
1.1: hydrogenchloride / methanol; dichloromethane; water / 3 h / 40 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere 2.2: 0.5 h / 20 °C / Inert atmosphere 3.1: sodium periodate / dichloromethane / 2 h / 22 °C / Inert atmosphere 3.2: Inert atmosphere 4.1: 1,4-dioxane / 0.08 h / 22 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 31 p. 12285 - 12292
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran T=20°C; 2: With hydrogenchloride in water pH=2.5 - 3;
参考文献
WO2008/121670 A1, ;
Page/Page column 72-73 ;
WO 2008/121670 A1
