4-(甲氧基甲基)-1,3-噻唑-2-胺合成路线 （共 5 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
T=20°C; 72 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/121110 A1, 2005 ;
Location in patent: Page/Page column 94 ;
WO 2005/121110 A1
反应条件
1: 1,1-dichloromethyl methyl ketone; thiourea T=55°C; 3 h;
2: methanol With magnesium sulfate
72 h; Heating / reflux;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1598349 A1, 2005 ;
Location in patent: Page/Page column 126 ;
反应条件
1: 1-methoxy-2-oxo-propane With bromine in methanol
T=0 - 20°C;
2: thiourea in methanol
T=20°C; Reflux;
参考文献
AMGEN INC.; ZENG, Qingping; YUAN, Chester Chenguang; YAO, Guomin; WANG, Xianghong; TADESSE, Seifu; ST. JEAN, JR., David J.; REICHELT, Andreas; LIU, Qingyian; HONG, Fang-Tsao; HAN, Nianhe; FOTSCH, Christopher H.; DAVIS, Carl D.; BOURBEAU, Matthew P.; ASHTON, Kate S.; ALLEN, John G.
Patent: WO2010/83246 A1, 2010 ;
Location in patent: Page/Page column 96-97 ;
反应条件
in methanol
Heating / reflux;
参考文献
Gubler, Marcel; Haap, Wolfgang; Hebeisen, Paul; Kitas, Eric A.; Kuhn, Bernd; Minder, Rudolf E.; Schott, Brigitte; Wessel, Hans P.
Patent: US2007/281979 A1, 2007 ;
Location in patent: Page/Page column 22 ;
反应条件
in methanol
2 h; Heating / reflux;
参考文献
AMGEN INC.
Patent: US2007/173506 A1, 2007 ;
Location in patent: Page/Page column 35 ;
