2-[(1,1-二甲基乙基)(苯基甲基)氨基]-1-[4-羟基-3-(羟基-甲基)苯基]乙酮沙丁胺醇合成路线 (共 3 条)
反应条件
sodium tetrahydroborate
参考文献
Collin; Hartley; Jack; Lunts; Press; Ritchie; Toon
Journal of medicinal chemistry, 1970 , vol. 13, # 4 p. 674 - 680
反应条件
1: NaBH4 2: H2 / Pd-C View Scheme
参考文献
Collin; Hartley; Jack; Lunts; Press; Ritchie; Toon
Journal of medicinal chemistry, 1970 , vol. 13, # 4 p. 674 - 680
反应条件
1: 3-(acetoxymethyl)-4-acetoxyacetophenone With bromine
0.5 h; Heating / reflux;
2: N-benzyl-t-butylamine 20 - 25 h; Heating / reflux;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US2005/9926 A1, 2005 ;
Location in patent: Page 2-3 ;