1,1-二氧代-六氢-1L6-硫基吡喃-4-甲酸合成路线 （共 6 条）
反应条件
poly-4-vinylpyridine in N,N-dimethyl-formamide
T=95°C; 0.166667 h; Microwave irradiation;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2010/9964 A1, 2010 ;
Location in patent: Page/Page column 74 ;
反应条件
1: With methanol; lithium hydroxide; water
T=20°C; 18 h;
2: With hydrogenchloride; water
1 h;
参考文献
PFIZER LIMITED
Patent: WO2006/136917 A1, 2006 ;
Location in patent: Page/Page column 35 ;
WO 2006/136917 A1
反应条件
1: With potassium hydroxide in tert-butyl alcohol
Heating / reflux;
2: With sulfuric acid in water
3 h; Acidic aqueous solutionHeating / reflux;
参考文献
TULARIK INC.
Patent: WO2004/43958 A1, 2004 ;
Location in patent: Page 56 ;
WO 2004/043958 A1
反应条件
hydrogenchloride in water
T=100°C; 8 h; Inert atmosphere;
参考文献
Bio, Matthew M.; Hansen, Karl B.; Gipson, John
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 892 - 895
反应条件
potassium permanganate
参考文献
Cockburn; McKay
Journal of the American Chemical Society, 1954 , vol. 76, p. 5703
反应条件
dimethylsulfide borane complex in dichloromethane
T=37°C; 2 h; Inert atmosphere;
参考文献
Bio, Matthew M.; Hansen, Karl B.; Gipson, John
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 892 - 895
