11beta,17alpha-二羟基-4-孕烯-3,20-二酮合成路线 （共 19 条）
反应条件
1: lithium alanate; diethyl ether; benzene 2: acetone; aqueous sulfuric acid 3: aqueous H2SO4 / nachfolgende Umsetzung mit Semicarbazid und mit Brenztraubensaeure View Scheme
参考文献
Journal of the American Chemical Society, , vol. 76, p. 546,550
反应条件
1: LiAlH4 / folgenden mit wss.HCl 3: CrO3; pyridine 4: benzene; toluene-4-sulfonic acid 5: lithium alanate; diethyl ether; benzene 6: acetone; aqueous sulfuric acid 7: aqueous H2SO4 / nachfolgende Umsetzung mit Semicarbazid und mit Brenztraubensaeure View Scheme
参考文献
Journal of the American Chemical Society, , vol. 76, p. 546,550
反应条件
acetic acid; sodium iodide
反应条件
2: NaI; acetic acid View Scheme
反应条件
1: 90 percent / ethylenediamine / toluene / 2 h 2: 32 percent / ethylenediamine / diethyl ether / 2 h 3: 82 percent / HgSO4 / methanol; tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 26, # 3 p. 285 - 289
Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 3 p. 84 - 87
反应条件
mit Hilfe von Curvularia lunata;
参考文献
Journal of the American Chemical Society, , vol. 77, p. 763
反应条件
1: 32 percent / ethylenediamine / diethyl ether / 2 h 2: 82 percent / HgSO4 / methanol; tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 26, # 3 p. 285 - 289
Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 3 p. 84 - 87
反应条件
1: 95 percent / α',α'-isobutyronitrile, HBu3Sn / tetrahydrofuran / 3.5 h / Heating 2: 32 percent / ethylenediamine / diethyl ether / 2 h 3: 82 percent / HgSO4 / methanol; tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 26, # 3 p. 285 - 289
Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 3 p. 84 - 87
反应条件
hydrogen sulfide; sodium iodide 1.) EtOH, DMF, reflux, 10 min, 2.) EtOH, DMF; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 27, # 8.1 p. 1479 - 1485
Zhurnal Organicheskoi Khimii, , vol. 27, # 8 p. 1686 - 1693
