3-(吡啶-3-基)丙酸乙酯合成路线 （共 28 条）
反应条件
in toluene
T=25°C; Equilibrium constant;
参考文献
Hunter, Christopher A.; Misuraca, Maria Cristina; Turega, Simon M.
Journal of the American Chemical Society, 2011 , vol. 133, # 3 p. 582 - 594
反应条件
in toluene
T=25°C; Equilibrium constant;
参考文献
Hunter, Christopher A.; Misuraca, Maria Cristina; Turega, Simon M.
Journal of the American Chemical Society, 2011 , vol. 133, # 3 p. 582 - 594
反应条件
diisobutylaluminium hydride in toluene
T=-78°C; 2 h;
参考文献
Voelker, Troy; Xia, Haiji; Fandrick, Keith; Johnson, Robert; Janowsky, Aaron; Cashman, John R.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 2047 - 2068
反应条件
1: NaH / 1,2-dimethoxy-ethane / 20 h / Ambient temperature
2: sodium methoxide / methanol / 18 h / Heating
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
参考文献
Graef et al.
Journal of Organic Chemistry, 1946 , vol. 11, p. 257,263
反应条件
1: sodium wire / diethyl ether / 18 h / Ambient temperature
2: ethanol / 7 h / Heating
3: 44 percent / NaOH / H2O; ethanol / 60 °C
4: 69 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: sodium wire / diethyl ether / 18 h / Ambient temperature
2: ethanol / 7 h / Heating
3: 44 percent / NaOH / H2O; ethanol / 60 °C
4: 58 percent / 2.) 2 N HBr / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
hydrazine in ethanol
18 h; Heating / reflux;
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: US6809107 B1, 2004 ;
Location in patent: Page/Page column 80 ;
