6-氯-5-氰基-2-甲基烟酸乙酯合成路线 （共 4 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
18 h; Reflux;
参考文献
Bach, Peter; Bostroem, Jonas; Brickmann, Kay; Van Giezen; Groneberg, Robert D.; Harvey, Darren M.; O'Sullivan, Michael; Zetterberg, Fredrik
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 360 - 375
反应条件
copper dichloride; isopentyl nitrite in acetonitrile
T=65°C; Sandmeyer reaction; 0.416667 h; Inert atmosphere;
参考文献
Da Silva, Daniel; Samadi, Abdelouahid; Chioua, Mourad; Do Carmo Carreiras, Maria; Marco-Contelles, Jose
Synthesis, 2010 , # 16 art. no. P05210SS, p. 2725 - 2730
反应条件
1.1: ethanol / 42 °C
1.2: 30 °C
1.3: 20 - 25 °C / pH 4 - 5
2.1: trichlorophosphate / acetonitrile / 20 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
View Scheme
参考文献
Bell, Stephen J.; McIntyre, Steve; Garcia, Conchita F.; Kitson, Sean L; Therkelsen, Frans; Andersen, Soren M; Zetterberg, Fredrik; Aurell, Carl-Johan; Bollmark, Martin; Ehrl, Robert
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 819 - 823
反应条件
1.1: sodium ethanolate / ethanol / 16 h / |Inert atmosphere
1.2: 0.17 h / |Inert atmosphere
2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 2 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Andersen, Soren M.; Aurell, Carl-Johan; Zetterberg, Fredrik; Bollmark, Martin; Ehrl, Robert; Schuisky, Peter; Witt, Anette
Organic Process Research and Development, 2013 , vol. 17, # 12 p. 1543 - 1551
