2-(7-氯-3H-吡唑并[4,3-d]嘧啶-3-基)乙醇合成路线 （共 3 条）
反应条件
1: 4,6-dichloro-pyrimidine-5-carboxaldehyde With triethylamine in tetrahydrofuran
T=0°C; 0.166667 h; Inert atmosphere;
2: 2-hydrazinoethanol in tetrahydrofuran
T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Morrill, Christie; Babu, Suresh; Almstead, Neilg.; Moon, Young-Choon
Synthesis (Germany), 2013 , vol. 45, # 13 art. no. SS-2013-C0248-OP, p. 1791 - 1806
反应条件
1: 4,6-dichloro-pyrimidine-5-carboxaldehyde With triethylamine in tetrahydrofuran
T=0°C; 0.166667 h; Inert atmosphere;
2: (2-hydroxyethyl)hydrazine hydrochloride in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Babu, Suresh; Morrill, Christie; Almstead, Neil G.; Moon, Young-Choon
Organic Letters, 2013 , vol. 15, # 8 p. 1882 - 1885
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=0°C; 3 h;
参考文献
Zacharie, Boulos; Connolly, Timothy P.; Rej, Rabindra; Attardo, Giorgio; Penney, Christopher L.
Tetrahedron, 1996 , vol. 52, # 7 p. 2271 - 2278
