4-环己基-3-氧代丁酸乙酯合成路线 （共 8 条）
反应条件
1: 4-carboxymethyl cyclohexane With triethylamine; isobutyl chloroformate in tetrahydrofuran T=-30 - -20°C; 0.5 h; 2: ethyl acetate With lithium diisopropyl amide in tetrahydrofuran T=-70 - -65°C; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22559 A1, 2004 ;
Location in patent: Page 32 ;
WO 2004/022559 A1
反应条件
sodium ethanolate in ethanol T=0 - 20°C; Inert atmosphere;
参考文献
PHENEX PHARMACEUTICALS AG; GEGE, Christian; KINZEL, Olaf; STEENECK, Christoph; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2014/23367 A1, 2014 ;
Location in patent: Page/Page column 109 ;
反应条件
lithium diisopropyl amide T=-70 - -65°C;
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22561 A1, 2004 ;
Location in patent: Page 56 ;
WO 2004/022561 A1
反应条件
1: propanedioic acid monoethyl ester With n-butyllithium in tetrahydrofuran; hexane T=-78 - -10°C; 2: cyclohexylacetic acid chloride in tetrahydrofuran; hexane T=-78°C; 0.166667 h; Further stages.;
参考文献
Lager, Erik; Nilsson, Jakob; stergaard Nielsen, Elsebet; Nielsen, Mogens; Liljefors, Tommy; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6936 - 6948
反应条件
1: 4-carboxymethyl cyclohexane With 1,1'-carbonyldiimidazole in tetrahydrofuran Acylation; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran Substitution; decarboxylation;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 6 p. 991 - 1002
反应条件
1: thionyl chloride 2: diethyl ether / Einleiten von Ammoniak in eine aether. Loesung des Reaktionsprodukts View Scheme
反应条件
diethyl ether Einleiten von Ammoniak in eine aether. Loesung des Reaktionsprodukts;
反应条件
pyridine 1.) CH2Cl2, 15 min, 0 deg C; 1 h, RT; 2.) 2 h, reflux; Yield given. Multistep reaction;
参考文献
Monatshefte fuer Chemie, , vol. 120, p. 891 - 898
