3-氯-1-(2,3-二氢-1H-吲哚-1-基)丙基-1-酮合成路线 （共 5 条）
反应条件
AlCl3, aluminium chloride T=140°C; 4 h;
参考文献
Yin, Lina; Lucas, Simon; Maurer, Frauke; Kazmaier, Uli; Hu, Qingzhong; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 14 p. 6629 - 6633
反应条件
in acetone
T=70°C; 3 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/15516 A1, 2008 ;
Location in patent: Page/Page column 36 ;
反应条件
2: LialH4
View Scheme
参考文献
Gawinecki, Ryszard; Kolehmainen, Erkki; Kauppinen, Reijo
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1998 , # 1 p. 25 - 30
反应条件
1: AlCl3, aluminium chloride; sodium chloride / 150 °C
2: N-bromosuccinmide / N,N-dimethyl-formamide / 0 °C
View Scheme
参考文献
Yin, Lina; Lucas, Simon; Maurer, Frauke; Kazmaier, Uli; Hu, Qingzhong; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 14 p. 6629 - 6633
反应条件
1: AlCl3, aluminium chloride / 4 h / 140 °C
2: AlCl3, aluminium chloride / dichloromethane / 18 h / 20 °C / Reflux
View Scheme
参考文献
Yin, Lina; Lucas, Simon; Maurer, Frauke; Kazmaier, Uli; Hu, Qingzhong; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 14 p. 6629 - 6633
