potassium hydroxide; water in methanol 2 h; Heating;

tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate in methoxybenzene T=100°C; Suzuki carbonylative coupling; P=760.051 Torr; 20 h; chemoselective reaction;

1: N-cyclohexyl-4-(methoxycarbonyl)benzamide With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 0°C; Inert atmosphere; 2: (4-Methylphenyl)-magnesium bromide in dichloromethane T=0°C; 0.416667 h; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane T=65°C; 3 h; Inert atmosphere; chemoselective reaction;

carbonylchlorohydridetris(triphenylphosphine) ruthenium(II); water; potassium carbonate in toluene T=110°C; 13 h; Inert atmosphereSealed tube;

1: 4-iodo-benzoic acid methyl ester With lithium chloride in N,N-dimethyl-formamide T=80°C; 12 h; 2: 4-methyl-benzoyl chloride With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; Inert atmosphere;

trifluoromethanesulfonic anhydride T=102°C; Friedel Crafts acylation; 2 h;

Cu(I) 3-methylsalicylate in N,N-dimethyl-formamide 1 h; Microwave irradiationHeatingInert atmosphereSealed tube;

aluminium trichloride

1: terephthalic acid monomethyl ester With thionyl chloride 2: toluene With aluminium trichloride T=25°C; Friedel-Crafts acylation;

1: CrO3; glacial acetic acid 2: hydrochloric acid View Scheme