反应条件
1: K2CO3
2: SnCl2
3: 81 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
4: 71 percent / Dess-Martin periodinane / CH2Cl2 / 0.5 h / 20 °C
5: 88 percent / Pd(PPh3)4; pyrrolidine; PPh3 / CH2Cl2 / 0.17 h / 20 °C
6: 28 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 4 h / 20 °C
View Scheme
参考文献
Tercel, Moana; Stribbling, Stephen M.; Sheppard, Hilary; Siim, Bronwyn G.; Wu, Kent; Pullen, Susan M.; Botting, K. Jane; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2132 - 2151