4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸合成路线 （共 7 条）
反应条件
water; lithium hydroxide hydrate in methanol T=20°C; 8 h;
参考文献
Kalesh, Karunakaran A.; Liu, Kai; Yao, Shao Q.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5129 - 5136
反应条件
1: With sodium hydroxide; ethanol 16 h; Heating / reflux; 2: With hydrogenchloride; water pH=~ 3 - 4;
参考文献
US2008/300268 A1, ;
Page/Page column 59-60 ;
反应条件
1: sulfuric acid / 12 h / |Reflux; |Inert atmosphere 2: hydrogenchloride / ethanol; water / 15 h / |Reflux 3: ammonium nitrate / 0.5 h / 0 °C 4: sodium hydroxide / butan-1-ol / 72 h / |Reflux; |Inert atmosphere 5: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C View Scheme
参考文献
Chemical Biology and Drug Design, , vol. 83, # 5 p. 592 - 599
反应条件
1: hydrogenchloride / ethanol; water / 15 h / |Reflux 2: ammonium nitrate / 0.5 h / 0 °C 3: sodium hydroxide / butan-1-ol / 72 h / |Reflux; |Inert atmosphere 4: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C View Scheme
参考文献
Chemical Biology and Drug Design, , vol. 83, # 5 p. 592 - 599
反应条件
1: sodium hydroxide / butan-1-ol / 72 h / |Reflux; |Inert atmosphere 2: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C View Scheme
参考文献
Chemical Biology and Drug Design, , vol. 83, # 5 p. 592 - 599
反应条件
1: ammonium nitrate / 0.5 h / 0 °C 2: sodium hydroxide / butan-1-ol / 72 h / |Reflux; |Inert atmosphere 3: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C View Scheme
参考文献
Chemical Biology and Drug Design, , vol. 83, # 5 p. 592 - 599
反应条件
1: 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid With thionyl chloride in 1-methyl-pyrrolidin-2-one T=60°C; 1.25 h; 2: 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine in 1-methyl-pyrrolidin-2-one T=90°C; 3 h; Product distribution / selectivity;
参考文献
US2010/16590 A1, ;
Page/Page column 20 ;
