2,5-二氯-3-苯基吡嗪合成路线 （共 30 条）
反应条件
1: aqueous H2O2; acetic acid
2: POCl3
3: aqueous HCl; acetic acid
4: POCl3 / 170 °C
View Scheme
参考文献
Karmas; Spoerri
Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
反应条件
1: aqueous HCl; acetic acid
2: POCl3 / 170 °C
View Scheme
参考文献
Karmas; Spoerri
Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
反应条件
1: aqueous HCl; acetic acid
2: POCl3 / 170 °C
View Scheme
参考文献
Karmas; Spoerri
Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
反应条件
1: POCl3
2: aqueous HCl; acetic acid
3: POCl3 / 170 °C
View Scheme
参考文献
Karmas; Spoerri
Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
反应条件
1: 10percent KOH / methanol / 1 h / Heating
2: POCl3, PCl5 / 1 h / 160 °C
3: 49 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h
4: POCl3 / 0.5 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: hydrazine hydrate / ethanol / 2 h / 140 °C
2: CuSO4*5H2O, / acetic acid; H2O / 1 h / Heating
3: 1 h / Heating
4: 10percent KOH / methanol / 1 h / Heating
5: POCl3, PCl5 / 1 h / 160 °C
6: 74 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h
7: POCl3 / 0.5 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: 1 h / Heating
2: 10percent KOH / methanol / 1 h / Heating
3: POCl3, PCl5 / 1 h / 160 °C
4: 74 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h
5: POCl3 / 0.5 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
trichlorophosphate
0.5 h; Heating; Yields of byproduct given;
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: 85 percent / 2N aq. NaOH / methanol; H2O / 1) -30 to 0 deg C, 2 h; 2) 40-50 deg C, 0.5 h
2: 47 percent / POCl3 / 1.5 h / Heating
3: 92 percent / POCl3 / 5 h / 180 - 185 °C / high pressure
View Scheme
参考文献
Sato, Nobuhiro
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 149 - 152
反应条件
1: 10percent KOH / methanol / 1 h / Heating
2: POCl3, PCl5 / 1 h / 160 °C
3: 74 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h
4: POCl3 / 0.5 h / Heating
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
