N,N-二甲基-1-(苯基甲基)-4-哌啶胺合成路线 （共 9 条）
参考文献
Journal of the Chemical Society, , p. 3165,3171
反应条件
1: With hydrogenchloride; ethanol; sodium cyanoborohydride; molecular sieve 3A T=20°C; pH=6; 168 h; 2: With sodium hydroxide in water
参考文献
WAKAMOTO PHARMACEUTICAL CO., LTD.
Patent: WO2006/51851 A1, 2006 ;
Location in patent: Page/Page column 84 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Kobashi, Seiichi; Kubo, Hajime; Yamauchi, Takayasu; Higashiyama, Kimio
Biological and Pharmaceutical Bulletin, 2002 , vol. 25, # 8 p. 1030 - 1034
反应条件
1: 45 percent / NaBH3CN / ethanol; HCl / 96 h / 20 °C / pH 6 2: 84 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 25, # 8 p. 1030 - 1034
反应条件
1: 99 percent / dimethylaminopyridine; trimethylamine / CH2Cl2 / 1 h / 0 °C / under nitrogen 2: 99 percent / HCl / methanol / 50 h / 20 °C 3: 45 percent / NaBH3CN / ethanol; HCl / 96 h / 20 °C / pH 6 4: 84 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 25, # 8 p. 1030 - 1034
反应条件
1: 99 percent / dimethylaminopyridine; trimethylamine / CH2Cl2 / 1 h / 0 °C / under nitrogen 2: 99 percent / HCl / methanol / 50 h / 20 °C 3: 45 percent / NaBH3CN / ethanol; HCl / 96 h / 20 °C / pH 6 4: 84 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 25, # 8 p. 1030 - 1034
反应条件
1: 99 percent / HCl / methanol / 50 h / 20 °C 2: 45 percent / NaBH3CN / ethanol; HCl / 96 h / 20 °C / pH 6 3: 84 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Biological and Pharmaceutical Bulletin, , vol. 25, # 8 p. 1030 - 1034
反应条件
ethanol T=130 - 140°C;
参考文献
Chemische Berichte, , vol. 74, p. 1648,1652
反应条件
hydrogen; palladium in methanol
参考文献
SmithKline Corporation
Patent: US3980788 A1, 1976 ;
