3-(5-溴-1-(4-氟苯基)-1,3-二氢异苯并呋喃-1-基)-N,N-二甲基丙烷-1-胺合成路线 （共 7 条）
反应条件
1: T=140 - 150°C; 6 h; 2: With N,N-dimethyl-formamide T=140 - 150°C; 0.0833333 h; 3: With ethylenediamine in water; toluene T=80°C; 0.416667 h;
参考文献
Sekhsaria Chemicals Limited
Patent: US2004/77870 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
in N,N-dimethyl-formamide; toluene
参考文献
Pharmachem Technologies Limited,
Patent: US2003/153774 A1, 2003 ;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; BHARGAV, Krishnaji, Upadhye; MISHRA, Krishna, Gopalji; FAROOQUI, Mohammed, Ismail
Patent: WO2005/42473 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With sodium cyanide; copper (I) cyanide in DMF (N,N-dimethyl-formamide); toluene T=154 - 159°C; Heating / reflux; 2: With sodium cyanide in DMF (N,N-dimethyl-formamide); water T=60 - 70°C; 3: With ethylenediamine in DMF (N,N-dimethyl-formamide); water; toluene
参考文献
Pharmachem Technologies Limited
Patent: JP2005/507900 A, 2005 ;
Location in patent: Page/Page column 27 ;
反应条件
in water; N,N-dimethyl-formamide; toluene
参考文献
Coppi, Laura; Gasanz Guillen, Yolanda; Campon Pardo, Julio
Patent: US2003/144534 A1, 2003 ;
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane
T=-5 - 20°C; 2 - 3 h;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; BHARGAV, Krishnaji, Upadhye; MISHRA, Krishna, Gopalji; FAROOQUI, Mohammed, Ismail
Patent: WO2005/42473 A1, 2005 ;
Location in patent: Page/Page column 10 ;
反应条件
1: With phosphoric acid in water
T=90°C; 1 h; Heating / reflux;
2: With ammonia in water; toluene
T=10 - 25°C;
参考文献
Pharmachem Technologies Limited
Patent: JP2005/507900 A, 2005 ;
Location in patent: Page/Page column 26 ;
