1-(4-氟苯基)-1-(3-二甲基氨基丙基)-5-氯二氢异苯并呋喃合成路线 (共 1 条)
反应条件
1: 5-chloro-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-phthalan With triphenylphosphine; nickel dichloride; zinc in acetonitrile 1.16667 h; Heating / reflux; 2: sodium cyanide in acetonitrile T=20°C; 15 h; Heating / reflux;
参考文献
ORION CORPORATION FERMION
Patent: WO2004/11450 A1, 2004 ;
Location in patent: Page 15, 16 ;