1-(4-氟苯基)-1,3-二氢异苯并呋喃-5-腈合成路线 （共 30 条）
反应条件
1: magnesium; 1-bromo-4-fluorobenzene With iodine in tetrahydrofuran 2: 5-cyano-isobenzofuran-1-one in tetrahydrofuran; dichloromethane T=-6 - -2°C;
参考文献
JUBILANT ORGANOSYS LTD.
Patent: WO2004/20425 A1, 2004 ;
Location in patent: Page 11 ;
反应条件
in N,N-dimethyl-formamide 6 h; Heating;
参考文献
Jin, Chunyang; Boldt, Karl G.; Rehder, Kenneth S.; Brine, George A.
Synthetic Communications, 2007 , vol. 37, # 6 p. 901 - 908
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 2: With water in ethanol 2 h;
参考文献
ORION CORPORATION FERMION
Patent: WO2004/11450 A1, 2004 ;
Location in patent: Page 16 ;
反应条件
sodium hydroxide; manganese(IV) dioxide; hydroxylamine hydrochloride; acetic anhydride; triethylamine in anhydrous xylene; n-heptane; water
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US2002/62040 A1, 2002 ;
反应条件
toluene-4-sulfonic acid in toluene T=80 - 85°C; 3 h;
参考文献
WO2005/77927 A1, ;
Page/Page column 8-9 ;
反应条件
hydroxylamine hydrochloride; acetic anhydride; triethylamine in toluene
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US6310222 B1, 2001 ;
反应条件
1: 1-(4-fluorophenyl)-1,3-dihydro-5-chloro-isobenzofuran With triphenylphosphine; nickel dichloride; zinc in acetonitrile T=20°C; 0.5 h; 2: potassium cyanide in acetonitrile 8 h; Reflux;
参考文献
Reddy, M. Pulla; Bhujanga Rao; Usharani; Dubey
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1829 - 1832
反应条件
in tetrahydrofuran; chloroform
参考文献
JUBILANT ORGANOSYS LTD.
Patent: WO2004/20425 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
oxalyl dichloride in 1,3-dimethyl-2-imidazolydinone; toluene T=18 - 32°C; 1.16667 - 1.66667 h; Product distribution / selectivity;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2006/57261 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
in trimethylbutyl radical T=0 - 25°C; 15.5 h; Purification / work up;
参考文献
WO2004/80988 A1, ;
Page 21 ;
