2-(碘甲基)-1,4-二恶烷合成路线 （共 4 条）
反应条件
1: 91 percent / K2CO3 / toluene / Heating 2: 6.59 g / H2 / 10percent Pd/C / ethanol / 20 h / 50 °C / 2585.81 Torr View Scheme
参考文献
Warawa; Migler; Ohnmacht; Needles; Gatos; McLaren; Nelson; Kirkland
Journal of Medicinal Chemistry, 2001 , vol. 44, # 3 p. 372 - 389
反应条件
iodine; sodium hydrogencarbonate in acetonitrile
T=20°C; 20 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 80 ;
参考文献
Tsivunin, V. S.; Zaripova, V. G.; Bikulova, V. Zh.; Zykova, V. V.
J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 4 p. 938 - 939,826 - 827
反应条件
18-crown-6 ether in N,N-dimethyl-formamide
T=80°C; 24 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 80 ;
