N-CBZ-羟脯氨酸甲酯合成路线 （共 28 条）
反应条件
sulfuric acid Esterification; Heating;
参考文献
Gregson, Stephen J.; Howard, Philip W.; Gullick, Darren R.; Hamaguchi, Anzu; Corcoran, Kathryn E.; Brooks, Natalie A.; Hartley, John A.; Jenkins, Terence C.; Patel, Sejal; Guille, Matthew J.; Thurston, David E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 5 p. 1161 - 1174
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C; 23 h;
参考文献
Maison; Arce; Renold; Kennedy; Kemp
Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10245 - 10254
反应条件
triethylamine in tetrahydrofuran T=20°C;
参考文献
PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
Location in patent: Page/Page column 82-83 ;
WO 2012/114223 A1
参考文献
Emery, Fabienne; Bisang, Christian; Favre, Michel; Jiang, Luyong; Robinson, John A.
Chemical Communications, 1996 , # 18 p. 2155 - 2156
反应条件
in diethyl ether T=0°C;
参考文献
Vanek, Vaclav; Budesinsky, Milos; Rinnova, Marketa; Rosenberg, Ivan
Tetrahedron, 2009 , vol. 65, # 4 p. 862 - 876
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 1 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/121135 A1, 2005 ;
Location in patent: Page/Page column 67-68 ;
反应条件
triethylamine in tetrahydrofuran; water T=20°C;
参考文献
WO2008/97676 A1, ;
Page/Page column 23-24 ;
WO 2008/097676 A1
反应条件
1: SOCl2 2: Et3N / methanol View Scheme
参考文献
Chemistry Letters, , vol. 36, # 4 p. 550 - 551
反应条件
1: methanol; (2S,4R)-2-carboxy-4-hydroxypyrrolidine With thionyl chloride T=20 - 65°C; 2: benzyl chloroformate With triethylamine in dichloromethane T=0°C; 0.5 h;
参考文献
WO2014/32 A1, ;
Page/Page column 57; 58 ;
反应条件
1: K2CO3, NaI / dimethylformamide / 16 h / Ambient temperature 2: 91 percent / methanol / 8 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 8 p. 2787 - 2800
