Inhoffen Lythgoe diol合成路线 （共 42 条）
反应条件
1: 89 percent / H2 / Lindlar catalyst 2: 72 percent / BF3*Et2O 3: H2 / PtO2 4: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
1: 72 percent / BF3*Et2O 2: H2 / PtO2 3: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
1: H2 / PtO2 2: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
1: 7.5 M KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C 2: 96 percent / 10percent DMAP / pyridine / 3 h / 70 °C 3: 89 percent / H2 / Lindlar catalyst 4: 72 percent / BF3*Et2O 5: H2 / PtO2 6: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
1: diisobutylaluminium hydride 2: oxalic acid / tetrahydrofuran / Linde 4A molecular sieves 3: 82 percent / 1.) titanium tetrachloride, 2,4,6-trimethylpyridine, 2.) 1 M hydrochloric acid / CH2Cl2 / 1.) -78 degC, 5 min., 2.) -78 degC to r.t. 4: pyridinium chlorochromate / CH2Cl2 / 18 h / 25 °C 5: 7.5 M KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C 6: 96 percent / 10percent DMAP / pyridine / 3 h / 70 °C 7: 89 percent / H2 / Lindlar catalyst 8: 72 percent / BF3*Et2O 9: H2 / PtO2 10: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
1: 82 percent / 1.) titanium tetrachloride, 2,4,6-trimethylpyridine, 2.) 1 M hydrochloric acid / CH2Cl2 / 1.) -78 degC, 5 min., 2.) -78 degC to r.t. 2: pyridinium chlorochromate / CH2Cl2 / 18 h / 25 °C 3: 7.5 M KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C 4: 96 percent / 10percent DMAP / pyridine / 3 h / 70 °C 5: 89 percent / H2 / Lindlar catalyst 6: 72 percent / BF3*Et2O 7: H2 / PtO2 8: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
1: pyridinium chlorochromate / CH2Cl2 / 18 h / 25 °C 2: 7.5 M KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C 3: 96 percent / 10percent DMAP / pyridine / 3 h / 70 °C 4: 89 percent / H2 / Lindlar catalyst 5: 72 percent / BF3*Et2O 6: H2 / PtO2 7: KOH / tetrahydrofuran; methanol; H2O / 48 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 4 p. 1138 - 1139
反应条件
hydrogen fluoride in acetonitrile 1.5 h; Ambient temperature;
参考文献
Mascarenas, J. L.; Mourino, A.; Castedo, L.
Journal of Organic Chemistry, 1986 , vol. 51, # 8 p. 1269 - 1272
反应条件
1: With 2,4,6-trimethyl-pyridine in dimethyl sulfoxide T=150°C; Oxidation; 0.666667 h; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene T=20°C; unknown; 48 h; 3: With sodium tetrahydroborate in methanol T=-20 - 20°C; Reduction;
参考文献
European Journal of Organic Chemistry, , # 9 p. 2241 - 2248
反应条件
1: t-BuOK / tetrahydrofuran / 63 h / Ambient temperature 2: 70 percent / 0.813M BF3*Et2O / CH2Cl2 / 2 h 3: 77 percent / H2 / 5 percent Pd/C / ethyl acetate / 735.5 Torr View Scheme
参考文献
Tetrahedron, , vol. 40, # 12 p. 2283 - 2296
