神经肽 C; 心脏兴奋肽合成路线 （共 14 条）
反应条件
dimercaptoethane; trifluorormethanesulfonic acid; methyl-phenyl-thioether in trifluoroacetic acid 1 h;
参考文献
Sakina; Kawazura; Morihara; Yajima
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4345 - 4354
反应条件
1: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h 2: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h 3: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 11 p. 4345 - 4354
反应条件
2: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h 3: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h 4: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 11 p. 4345 - 4354
反应条件
2: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h 3: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h 4: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 11 p. 4345 - 4354
反应条件
1: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h 2: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h 3: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 11 p. 4345 - 4354
反应条件
1: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h 2: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 11 p. 4345 - 4354
反应条件
thermolysin in methanol 3 h; Ambient temperatureeffect of the pH, conc. of MeOH, reaction time; Product distribution;
参考文献
Sakina; Kawazura; Morihara; Yajima
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4345 - 4354
反应条件
hydrogen catalytic hydrogenolysis;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 53, # 2 p. 486,427 - 428
反应条件
1: mixed anhydride method 2: mixed anhydride method 3: H2 / catalytic hydrogenolysis View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 53, # 2 p. 486,427 - 428
反应条件
1: mixed anhydride method 2: mixed anhydride method 3: mixed anhydride method 4: H2 / catalytic hydrogenolysis View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 53, # 2 p. 486,427 - 428
