(1S,2S)-(-)-2-氨基-1-环戊烷羧酸合成路线 （共 9 条）
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
反应条件
1: AcOH / ethanol
2: NaCNBH3
3: LiOH
4: H2 / Pd/C
View Scheme
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
反应条件
hydrogen; palladium on activated charcoal
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
反应条件
1: LiOH
2: H2 / Pd/C
View Scheme
参考文献
Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Yamazaki, Toshimasa; Zhu, Yun-Fei; Probstl, Albert; Chadha, Raj K.; Goodman, Murray
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6644 - 6655
反应条件
trifluoroacetic acid
T=20°C; 12 h;
参考文献
Sakai, Takeo; Doi, Hirohisa; Tomioka, Kiyoshi
Tetrahedron, 2006 , vol. 62, # 35 p. 8351 - 8359
反应条件
1: 95 percent / NCS / CH2Cl2 / -20 °C
2: 6-(dibutylamino)-1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 48 h / 20 °C
3: 56 percent / NH2OH*HCl / tetrahydrofuran; H2O / 0.25 h / 20 °C
4: 40 percent / CF3CO2H / 12 h / 20 °C
View Scheme
参考文献
Sakai, Takeo; Doi, Hirohisa; Tomioka, Kiyoshi
Tetrahedron, 2006 , vol. 62, # 35 p. 8351 - 8359
反应条件
1: 77 percent / KN(SiMe3)2 / 2-methyl-propan-2-ol; tetrahydrofuran; toluene / 0.25 h / 20 °C
2: 95 percent / NCS / CH2Cl2 / -20 °C
3: 6-(dibutylamino)-1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 48 h / 20 °C
4: 56 percent / NH2OH*HCl / tetrahydrofuran; H2O / 0.25 h / 20 °C
5: 40 percent / CF3CO2H / 12 h / 20 °C
View Scheme
参考文献
Sakai, Takeo; Doi, Hirohisa; Tomioka, Kiyoshi
Tetrahedron, 2006 , vol. 62, # 35 p. 8351 - 8359
反应条件
1: 6-(dibutylamino)-1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 48 h / 20 °C
2: 56 percent / NH2OH*HCl / tetrahydrofuran; H2O / 0.25 h / 20 °C
3: 40 percent / CF3CO2H / 12 h / 20 °C
View Scheme
参考文献
Sakai, Takeo; Doi, Hirohisa; Tomioka, Kiyoshi
Tetrahedron, 2006 , vol. 62, # 35 p. 8351 - 8359
