(1S,2R)-2-氨基环戊烷甲酸合成路线 （共 18 条）
反应条件
potassium hydroxide in 1,4-dioxane; water 20 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/15166 A1, 2009 ;
Location in patent: Page/Page column 76-77 ;
WO 2009/015166 A1
反应条件
hydrogen; triethylamine; palladium dihydroxide in ethanol
T=40°C; P=760.051 Torr; 4 h;
参考文献
Aggarwal, Varinder K.; Roseblade, Stephen J.; Barrell, Juliet K.; Alexander, Rikki
Organic Letters, 2002 , vol. 4, # 7 p. 1227 - 1229
反应条件
hydrogen; palladium on activated charcoal in methanol
T=20°C;
参考文献
Cimarelli; Palmieri; Volpini
Synthetic Communications, 2001 , vol. 31, # 19 p. 2943 - 2953
反应条件
palladium 10 on activated carbon; hydrogen in methanol
T=65°C; P=45603.1 Torr; 24 h;
参考文献
Pou, Ana; Moyano, Albert
European Journal of Organic Chemistry, 2013 , # 15 p. 3103 - 3111
反应条件
1: 73 percent / NaHB(OAc)3; AcOH / acetonitrile / 2 h / 0 °C
2: 87 percent / H2 / Pd/C / methanol / 20 °C
View Scheme
参考文献
Cimarelli; Palmieri; Volpini
Synthetic Communications, 2001 , vol. 31, # 19 p. 2943 - 2953
反应条件
methylamine in ethanol
1.5 h; Ambient temperature;
参考文献
Theil, Fritz; Ballschuh, Sibylle
Tetrahedron Asymmetry, 1996 , vol. 7, # 12 p. 3565 - 3572
反应条件
1: 80 percent / LiOH*H2O / tetrahydrofuran / 4 h / 80 °C
2: PdCl2(CH3CN)2 / acetone / 1 h / 60 °C
3: NaHCO3 / acetone / 12 h / 60 °C
4: 65 percent / H2 / Pd/C / acetic acid / 48 h / 40 °C / 5171.62 Torr
5: 85 percent / Et3N; H2 / Pd(OH)2/C / ethanol / 4 h / 40 °C / 760.05 Torr
View Scheme
参考文献
Aggarwal, Varinder K.; Roseblade, Stephen J.; Barrell, Juliet K.; Alexander, Rikki
Organic Letters, 2002 , vol. 4, # 7 p. 1227 - 1229
反应条件
1: PdCl2(CH3CN)2 / acetone / 1 h / 60 °C
2: NaHCO3 / acetone / 12 h / 60 °C
3: 65 percent / H2 / Pd/C / acetic acid / 48 h / 40 °C / 5171.62 Torr
4: 85 percent / Et3N; H2 / Pd(OH)2/C / ethanol / 4 h / 40 °C / 760.05 Torr
View Scheme
参考文献
Aggarwal, Varinder K.; Roseblade, Stephen J.; Barrell, Juliet K.; Alexander, Rikki
Organic Letters, 2002 , vol. 4, # 7 p. 1227 - 1229
反应条件
1: 65 percent / H2 / Pd/C / acetic acid / 48 h / 40 °C / 5171.62 Torr
2: 85 percent / Et3N; H2 / Pd(OH)2/C / ethanol / 4 h / 40 °C / 760.05 Torr
View Scheme
参考文献
Aggarwal, Varinder K.; Roseblade, Stephen J.; Barrell, Juliet K.; Alexander, Rikki
Organic Letters, 2002 , vol. 4, # 7 p. 1227 - 1229
反应条件
1: (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; benzoic acid / toluene / 72 h / 4 °C
2: dipyridinium dichromate / dichloromethane / 20 °C / |Molecular sieve
3: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 65 °C / 45603.1 Torr
View Scheme
参考文献
Pou, Ana; Moyano, Albert
European Journal of Organic Chemistry, 2013 , # 15 p. 3103 - 3111
