丁氧羰基-亮氨酰-羟基化脯氨酸合成路线 （共 10 条）
反应条件
hydrogen; palladium in methanol
参考文献
Sato; Nagai
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 11 p. 3329 - 3336
反应条件
bis(tri-n-butyltin)oxide in toluene
T=90°C; 96 h;
参考文献
Salomon, Claudio J.; Mata, Ernesto G.; Mascaretti, Oreste A.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 10 p. 995 - 999
反应条件
tetrabutyl ammonium fluoride in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Namikoshi, Michio; Kundu, Bijoy; Rinehart, Kenneth L.
Journal of Organic Chemistry, 1991 , vol. 56, # 18 p. 5464 - 5466
反应条件
phosphate buffer; oxygen; tyrosinase in water; acetonitrile
T=20°C; pH=7.0; 19 h;
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: HATU; Hunig's base / acetonitrile
2: Ba(OH)2 / methanol
View Scheme
参考文献
Robinson, Jennifer L.; Taylor, Rachel E.; Liotta, Lisa A.; Bolla, Megan L.; Azevedo, Enrique V.; Medina, Irene; McAlpine, Shelli R.
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2147 - 2150
反应条件
1: Et3N / dimethylformamide / Ambient temperature
2: 100 percent / H2 / Pd black / methanol
View Scheme
参考文献
Sato; Nagai
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 11 p. 3329 - 3336
反应条件
1: 89 percent / tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 16 h / 20 °C / pH 7.0
2: 80 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HOBt / CH2Cl2 / 0 - 20 °C
3: tyrosinase; phosphate buffer; O2 / H2O; acetonitrile / 19 h / 20 °C / pH 7.0
View Scheme
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
1: HATU; Hunig's base / acetonitrile
2: Ba(OH)2 / methanol
View Scheme
参考文献
Robinson, Jennifer L.; Taylor, Rachel E.; Liotta, Lisa A.; Bolla, Megan L.; Azevedo, Enrique V.; Medina, Irene; McAlpine, Shelli R.
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2147 - 2150
反应条件
1.1: 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / -15 °C
1.2: 91.7 percent / N-methylmorpholine / dimethylformamide / 20 °C
2.1: 95.9 percent / aq. NaOH / methanol / 2 h / 20 °C
View Scheme
参考文献
Kumara; Channe Gowda; Rangappa
International Journal of Chemical Kinetics, 2002 , vol. 34, # 7 p. 438 - 444
参考文献
Kumara; Channe Gowda; Rangappa
International Journal of Chemical Kinetics, 2002 , vol. 34, # 7 p. 438 - 444
