反应条件
1: 3-hydroxy-pyridine With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.2 h;
2: 2-bromomethyl-1-chloro-4-nitro-benzene in N,N-dimethyl-formamide
T=0°C; 1 h;
参考文献
Gill, Adrian L.; Frederickson, Martyn; Cleasby, Anne; Woodhead, Steven J.; Carr, Maria G.; Woodhead, Andrew J.; Walker, Margaret T.; Congreve, Miles S.; Devine, Lindsay A.; Tisi, Dominic; O'Reilly, Marc; Seavers, Lisa C. A.; Davis, Deborah J.; Curry, Jayne; Anthony, Eachel; Padova, Alessandro; Murray, Christopher W.; Carr, Robin A. E.; Jhoti, Harren
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 414 - 426
