6-甲氧基-2,3,4,9-四氢-1H-咔唑-3-胺合成路线 （共 13 条）
反应条件
sulfuric acid in water
T=95 - 100°C;
参考文献
Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
反应条件
hydrazine hydrate in ethanol; chloroform
Ambient temperature;
参考文献
Glennon, Richard A.; Hong, Seoung-Soo; Bondarev, Mikhail; Law, Ho; Dukat, Malgorzata; Rakhit, Suman; Power, Patricia; Fan, Ermei; Kinneau, Diana; Kamboj, Rajender; Teitler, Milt; Herrick-Davis, Katharine; Smith, Carol
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 314 - 322
反应条件
hydrogen; palladium on activated charcoal in methanol
P=2585.7 Torr; 24 h; Ambient temperature; Yield given;
参考文献
Bird, C. W.; Wee, A. G. H.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 191 - 192
反应条件
1: 1) acetic acid / 1) ethanol, reflux, 10 min, 2) acetic acid, reflux, 4 h
2: aq. KOH; ethanol / 6 h / Heating
3: pyridine / 24 h
4: sodium azide / dimethylsulfoxide / 10 h / 100 °C
5: H2 / 10percent Pd/C / methanol / 24 h / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Bird, C. W.; Wee, A. G. H.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 191 - 192
反应条件
1: aq. KOH; ethanol / 6 h / Heating
2: pyridine / 24 h
3: sodium azide / dimethylsulfoxide / 10 h / 100 °C
4: H2 / 10percent Pd/C / methanol / 24 h / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Bird, C. W.; Wee, A. G. H.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 191 - 192
反应条件
1: pyridine / 24 h
2: sodium azide / dimethylsulfoxide / 10 h / 100 °C
3: H2 / 10percent Pd/C / methanol / 24 h / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Bird, C. W.; Wee, A. G. H.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 191 - 192
反应条件
1: sodium azide / dimethylsulfoxide / 10 h / 100 °C
2: H2 / 10percent Pd/C / methanol / 24 h / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Bird, C. W.; Wee, A. G. H.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 191 - 192
反应条件
1: 1) acetic acid / 1) ethanol, reflux, 10 min, 2) acetic acid, reflux, 4 h
2: aq. KOH; ethanol / 6 h / Heating
3: pyridine / 24 h
4: sodium azide / dimethylsulfoxide / 10 h / 100 °C
5: H2 / 10percent Pd/C / methanol / 24 h / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Bird, C. W.; Wee, A. G. H.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 191 - 192
反应条件
1: 86 percent / aq. K2CO3 / 0.5 h / Ambient temperature
2: 95 percent / PCC, molecular sieves 4A / CH2Cl2 / 3 h
3: 96 percent / HOAc / 2 h / Heating
4: 83 percent / hydrazine hydrate / CHCl3; ethanol / Ambient temperature
View Scheme
参考文献
Glennon, Richard A.; Hong, Seoung-Soo; Bondarev, Mikhail; Law, Ho; Dukat, Malgorzata; Rakhit, Suman; Power, Patricia; Fan, Ermei; Kinneau, Diana; Kamboj, Rajender; Teitler, Milt; Herrick-Davis, Katharine; Smith, Carol
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 314 - 322
反应条件
1: 96 percent / HOAc / 2 h / Heating
2: 83 percent / hydrazine hydrate / CHCl3; ethanol / Ambient temperature
View Scheme
参考文献
Glennon, Richard A.; Hong, Seoung-Soo; Bondarev, Mikhail; Law, Ho; Dukat, Malgorzata; Rakhit, Suman; Power, Patricia; Fan, Ermei; Kinneau, Diana; Kamboj, Rajender; Teitler, Milt; Herrick-Davis, Katharine; Smith, Carol
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 314 - 322
