1-苄基氮杂丁烷-3,3-二羧酸二乙酯合成路线 （共 3 条）
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=70°C; 2 h;
参考文献
Miller, Ross A.; Lang, Fengrui; Marcune, Benjamin; Zewge, Daniel; Song, Zhiguo J.; Karady, Sandor
Synthetic Communications, 2003 , vol. 33, # 19 p. 3347 - 3353
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 1.5 h / -10 °C
2: N,N-diisopropylethylamine / acetonitrile / 2 h / 70 °C
View Scheme
参考文献
Miller, Ross A.; Lang, Fengrui; Marcune, Benjamin; Zewge, Daniel; Song, Zhiguo J.; Karady, Sandor
Synthetic Communications, 2003 , vol. 33, # 19 p. 3347 - 3353
反应条件
1: potassium hydrogencarbonate / water / 3 h / 20 °C
2: acetonitrile / 0.67 h / -20 °C
3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / -10 °C / Reflux
View Scheme
参考文献
Sun, Yanyan; Gou, Shaohua; Yin, Runting; Jiang, Pingyuan
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5146 - 5153
