2-氯甲酰基-2-甲基丙酸乙酯合成路线 （共 9 条）
反应条件
phosphorus pentachloride T=90°C;
反应条件
zinc in methyl acetate
参考文献
Journal of Organic Chemistry, , vol. 55, # 24 p. 5982 - 5986
反应条件
(i) NaOEt, EtOH, (ii) KOH, EtOH, (iii) SOCl2; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 91, p. 2993 - 3002
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 22, p. 211 - 216
反应条件
potassium hydrogencarbonate in ethyl acetate T=0°C; 1.5 h;
参考文献
Gandolfi, Carmelo A.; Domenico, Roberto Di; Spinelli, Silvano; Gallico, Licia; Fiocchi, Luigi; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 3 p. 508 - 525
反应条件
in toluene Rosemund reduction;
参考文献
Cook, Barry; Dingwall, John G.
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 22, p. 211 - 216
反应条件
1: diethyl ether 2: 57 percent / LiAlH4 / tetrahydrofuran / 96 h / Heating View Scheme
参考文献
Huang, Yande; Yu, Jaehoon; Bentrude, Wesley G.
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4767 - 4773
参考文献
Setzer, William N.; Sopchik, Alan E.; Bentrude, Wesley G.
Journal of the American Chemical Society, 1985 , vol. 107, p. 2083 - 2091
反应条件
1: toluene / Rosemund reduction
2: 68 percent / TiCl4, N-methylmorpholine / tetrahydrofuran; CCl4 / 22 h / 0 °C
3: 73 percent / H2 / PtO2 / ethanol / 7 h / 100 °C / 76000 Torr
4: 57 percent / NaH / dioxane / 1.) r.t., 4 h, 2.) reflux, 2 h
5: 69 percent / conc. HCl / 24 h / Heating
View Scheme
参考文献
Cook, Barry; Dingwall, John G.
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 22, p. 211 - 216
