4-(4-硝基苄基)吗啡啉合成路线 (共 16 条)
反应条件
potassium carbonate in dimethyl sulfoxide T=90°C; 3 h;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
potassium hydroxide in water T=50°C; 3 h; Green chemistry;
参考文献
Chen, Wen-Xin; Zhang, Cai-Yun; Shao, Li-Xiong
Tetrahedron, 2014 , vol. 70, # 4 p. 880 - 885
反应条件
(η3-allyl)2Pd(cod)BF4; triethylamine; di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in ethanol T=75°C; 4 h; Inert atmosphere; regioselective reaction;
参考文献
Blessley, George; Holden, Patrick; Walker, Matthew; Brown, John M.; Gouverneur, Veronique
Organic Letters, 2012 , vol. 14, # 11 p. 2754 - 2757
反应条件
in tetrahydrofuran T=20°C; benzylation;
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=18°C; 2 h; Green chemistry; Solvent;
参考文献
McGonagle, Fiona I.; MacMillan, Donna S.; Murray, Jane; Sneddon, Helen F.; Jamieson, Craig; Watson, Allan J. B.
Green Chemistry, 2013 , vol. 15, # 5 p. 1159 - 1165
反应条件
triethylamine in dichloromethane T=40°C;
参考文献
Organic Letters, , vol. 6, # 16 p. 2657 - 2660
反应条件
1: C16H18NO6P With RuCl2(tricyclohexylphosphine)2(benzylidene) in dichloromethane T=50°C; Inert atmosphere; 2: morpholine With tetra-(n-butyl)ammonium iodide; potassium carbonate in chloroform T=80°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 13 p. 2904 - 2907
反应条件
di-tert-butylnitroxide radical in N,N-dimethyl-formamide Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 56, # 11 p. 3475 - 3479
反应条件
di-tert-butylnitroxide radical in N,N-dimethyl-formamide Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 56, # 11 p. 3475 - 3479
反应条件
1: polymer supported perruthenate / toluene / 2 h / 80 °C 2: polymer supported cyanoborohydride / methanol; toluene / 72 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 15 p. 2239 - 2241