4-(3-溴丙基)吡啶氢溴酸合成路线 （共 6 条）
参考文献
Elpern et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1951,1954
反应条件
hydrogen bromide
Heating;
参考文献
Abou-Gharbia; Patel; Moyer; Muth
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1100 - 1105
反应条件
1: 1.) Na, NH3 (liq.) / 1.) -78 deg C, 1 h, 2.) RT, overnight
2: 48percent HBr / Heating
View Scheme
参考文献
Abou-Gharbia; Patel; Moyer; Muth
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1100 - 1105
反应条件
1: 68 percent
2: 96 percent
3: 87 percent / H2O; methanol
View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
1: 68 percent
2: 96 percent
3: 87 percent / H2O; methanol
4: 94 percent
View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
sodium hydroxide
1.) benzene, water, 10-15 deg C, 2.) benzene, water, 10 deg C to RT, overnight; Yield given. Multistep reaction;
参考文献
Fabio; Lang Jr.; Lin; Tomcufcik
Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 201 - 206
