2-(2-吡啶)-4(3H)-嘧啶酮合成路线 （共 4 条）
反应条件
1: With sodium ethanolate in ethanol
18 h; Heating / reflux;
2: With hydrogenchloride in water
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/82884 A2, 2005 ;
Location in patent: Page/Page column 10 ;
WO 2005/082884 A2
反应条件
pyridine 1-oxide; Pd-Pt/C in pyridine
T=140 - 150°C; 18 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Murakoshi, Isamu; Sekine, Toshikazu; Higuchi, Yoshihiro; Ohyama, Nobuyuki; Yamada, Tomoko
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 1984 - 1986
反应条件
Pd-Pt/C in pyridine
T=140 - 150°C; 18 h; Yields of byproduct given;
参考文献
Murakoshi, Isamu; Sekine, Toshikazu; Higuchi, Yoshihiro; Ohyama, Nobuyuki; Yamada, Tomoko
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 1984 - 1986
反应条件
trichlorophosphate
3 h; Heating;
参考文献
Medwid, Jeffrey B.; Paul, Rolf; Baker, Jannie S.; Brockman, John A.; Du, Mila T.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1230 - 1241
