sodium hydroxide in tetrahydrofuran; methanol T=25°C;

1.1: Ph3P / tetrahydrofuran / 0.08 h / 0 °C 1.2: 45 percent / diethyl azodicarboxylate / tetrahydrofuran / 48 h / 0 - 25 °C 2.1: Zn; pyridine / NiCl2(H2O)6 / tetrahydrofuran / 0.25 h / 65 °C 2.2: 70 percent / tetrahydrofuran / 56 h / 65 °C 3.1: 69 percent / aq. NaOH / tetrahydrofuran; methanol / 25 °C View Scheme

1.1: Zn; pyridine / NiCl2(H2O)6 / tetrahydrofuran / 0.25 h / 65 °C 1.2: 70 percent / tetrahydrofuran / 56 h / 65 °C 2.1: 69 percent / aq. NaOH / tetrahydrofuran; methanol / 25 °C View Scheme

1.1: Ph3P / tetrahydrofuran / 0.08 h / 0 °C 1.2: 45 percent / diethyl azodicarboxylate / tetrahydrofuran / 48 h / 0 - 25 °C 2.1: Zn; pyridine / NiCl2(H2O)6 / tetrahydrofuran / 0.25 h / 65 °C 2.2: 70 percent / tetrahydrofuran / 56 h / 65 °C 3.1: 69 percent / aq. NaOH / tetrahydrofuran; methanol / 25 °C View Scheme

suspension of male Wistar rat liver mitochondria; nicotinamide adenine dinucleotide; magnesium chloride in various solvent(s) T=37°C; 0.5 h; biotransformation;