1: With boron trifluoride diethyl etherate in dichloromethane T=-78°C; 2 h; 2: T=0°C; 1 h;

1.1: CuBr2 / ethyl acetate / 80 °C 2.1: water / methanol / 2 h / Heating 3.1: diethyl ether / 0.25 h / -78 °C 3.2: 57 percent / 18 h / 20 °C 4.1: boron trifluoride diethyl etherate / CH2Cl2 / 2 h / -78 °C 4.2: 41 percent / 1 h / 0 °C View Scheme

1.1: diethyl ether / 0.25 h / -78 °C 1.2: 57 percent / 18 h / 20 °C 2.1: boron trifluoride diethyl etherate / CH2Cl2 / 2 h / -78 °C 2.2: 41 percent / 1 h / 0 °C View Scheme

1.1: water / methanol / 2 h / Heating 2.1: diethyl ether / 0.25 h / -78 °C 2.2: 57 percent / 18 h / 20 °C 3.1: boron trifluoride diethyl etherate / CH2Cl2 / 2 h / -78 °C 3.2: 41 percent / 1 h / 0 °C View Scheme

horseradish peroxidase in ethanol; water T=37°C; 2 h; Kinetics;