4-(苄基氨基)-2-(甲基磺酰基)嘧啶-5-羧酰胺合成路线 （共 5 条）
反应条件
1-methyl-pyrrolidin-2-one; 3-chloro-benzenecarboperoxoic acid
3 h;
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
反应条件
1: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; NH4OH / dimethylformamide; H2O / 16 h / 20 °C
2: 91 percent / N-methylpyrrolidinone; m-chloroperbenzoic acid / 3 h
View Scheme
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
反应条件
1: 96 percent / ethyldiisopropylamine / acetonitrile / 5 h / 20 °C
2: 100 percent / NaOH / methanol; tetrahydrofuran / 5 h / 50 °C
3: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; NH4OH / dimethylformamide; H2O / 16 h / 20 °C
4: 91 percent / N-methylpyrrolidinone; m-chloroperbenzoic acid / 3 h
View Scheme
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
反应条件
1: 100 percent / NaOH / methanol; tetrahydrofuran / 5 h / 50 °C
2: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; NH4OH / dimethylformamide; H2O / 16 h / 20 °C
3: 91 percent / N-methylpyrrolidinone; m-chloroperbenzoic acid / 3 h
View Scheme
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
反应条件
1: 96 percent / ethyldiisopropylamine / acetonitrile / 5 h / 20 °C
2: 100 percent / NaOH / methanol; tetrahydrofuran / 5 h / 50 °C
3: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; NH4OH / dimethylformamide; H2O / 16 h / 20 °C
4: 91 percent / N-methylpyrrolidinone; m-chloroperbenzoic acid / 3 h
View Scheme
参考文献
Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055
