5-氧代-1-苯基吡咯烷-3-羧酸甲酯合成路线 （共 7 条）
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 168 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 163-164 ;
WO 2010/142801 A1
反应条件
sulfuric acid in dichloromethane
Heating;
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
1: 93.3 percent / Heating
2: 90.5 percent / conc. H2SO4 / CH2Cl2 / Heating
View Scheme
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
1: 93.3 percent / Heating
2: 90.5 percent / conc. H2SO4 / CH2Cl2 / Heating
View Scheme
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
参考文献
Lipp et al.
Chemische Berichte, 1958 , vol. 91, p. 2239,2241,2245
参考文献
Mead Johnson and Co.
Patent: US2826588 , 1955 ;
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran
2 h; Heating;
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
