N2-异丁酰基鸟苷一水合物合成路线 （共 17 条）
反应条件
1: D-guanosine With pyridine; chloro-trimethyl-silane T=20°C; 2 h; 2: isobutyryl chloride T=0 - 20°C;
参考文献
Vertuani, Silvia; Baldisserotto, Anna; Varani, Katia; Borea, Pier Andrea; De Marcos Maria Cruz, Bonache; Ferraro, Luca; Manfredini, Stefano; Dalpiaz, Alessandro
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 202 - 209
反应条件
1: D-guanosine With pyridine; chloro-trimethyl-silane 2 h; 2: 2-methylpropanoic anhydride T=20°C; 4 h; 3: With ammonia; water T=0°C; 0.416667 h;
参考文献
Japan Science and Technology Agency
Patent: EP1604995 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: D-guanosine With pyridine; chloro-trimethyl-silane 2 h; 2: 2-methylpropanoic anhydride With pyridine T=20°C; 4 h; 3: With ammonium hydroxide 0.25 h;
参考文献
Xu, Yan; Ikeda, Reiko; Sugiyama, Hiroshi
Journal of the American Chemical Society, 2003 , vol. 125, # 44 p. 13519 - 13524
反应条件
chloro-trimethyl-silane; conc. ammonia in pyridine; methanol; dichloromethane; chloroform; water
反应条件
sodium methylate in 1,4-dioxane; methanol 0.25 h; Ambient temperature;
参考文献
Flockerzi, Dieter; Silber, Gunter; Charubala, Ramamurthy; Schlosser, Wilhelm; Varma, Rajendra Singh; et al.
Liebigs Annalen der Chemie, 1981 , # 9 p. 1568 - 1585
反应条件
pyridine T=20°C; 5 h;
参考文献
Wexselblatt, Ezequiel; Katzhendler, Jehoshua; Saleem-Batcha, Raspudin; Hansen, Guido; Hilgenfeld, Rolf; Glaser, Gad; Vidavski, Roee R.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4485 - 4497
反应条件
1: pyridine / 1.25 h / 20 °C 2: 75 percent / pyridine / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 25, # 2 p. 203 - 229
反应条件
Dowex 50 resin in tetrahydrofuran; methanol 0.5 h;
参考文献
Tetrahedron, , vol. 42, # 7 p. 1995 - 2004
反应条件
pyridine T=0 - 20°C; Inert atmosphere;
参考文献
Wexselblatt, Ezequiel; Katzhendler, Jehoshua; Saleem-Batcha, Raspudin; Hansen, Guido; Hilgenfeld, Rolf; Glaser, Gad; Vidavski, Roee R.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4485 - 4497
反应条件
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h 2: hydrogenchloride; water; lithium iodide / acetonitrile View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 30, # 7-8 p. 565 - 576
