potassium hydroxide in methanol 2 h; Heating;

dirhodium tetraacetate in 1,2-dichloro-ethane T=25°C; 1 h; Inert atmosphere; regioselective reaction;

sulfuric acid in acetic acid T=10°C;

dirhodium tetraacetate in 1,2-dichloro-ethane T=25°C; 1 h; Inert atmosphere; regioselective reaction;

1.1: 4-Acetylaminobenzenesulfonyl Azide / tetrahydrofuran / 0.08 h / Inert atmosphere 1.2: 12 h / 25 °C / Inert atmosphere 2.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere View Scheme

1.1: hydrogenchloride / water / 3 h / Reflux 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethylene glycol dimethyl ether; water / 0.08 h 2.2: 12 h / 100 °C 3.1: 4-Acetylaminobenzenesulfonyl Azide / tetrahydrofuran / 0.08 h / Inert atmosphere 3.2: 12 h / 25 °C / Inert atmosphere 4.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere View Scheme

1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethylene glycol dimethyl ether; water / 0.08 h 1.2: 12 h / 100 °C 2.1: 4-Acetylaminobenzenesulfonyl Azide / tetrahydrofuran / 0.08 h / Inert atmosphere 2.2: 12 h / 25 °C / Inert atmosphere 3.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere View Scheme

1: 1.) Mg or n-C4H9Li / 1.) ether or THF, 2.) reflux, 2 h 2: 75 percent / 96percent H2SO4 / acetic acid / 10 °C View Scheme

1: 1.) Mg or n-C4H9Li / 1.) ether or THF, 2.) reflux, 2 h 2: 75 percent / 96percent H2SO4 / acetic acid / 10 °C View Scheme

hydrogenchloride