2-(3-硝基吡啶-2-基)丙二酸二乙酯合成路线 （共 17 条）
反应条件
in N,N-dimethyl-formamide
参考文献
Zeneca Limited
Patent: US6294532 B1, 2001 ;
反应条件
in dimethyl sulfoxide
参考文献
Wood, Edgar R.; Kuyper, Lee; Petrov, Kimberly G.; Hunter III, Robert N.; Harris, Philip A.; Lackey, Karen
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 953 - 957
反应条件
in N,N-dimethyl-formamide
T=0°C;
参考文献
Kuzmich, Daniel; Mulrooney, Carol
Synthesis, 2003 , # 11 p. 1671 - 1678
反应条件
1.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction
2.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction
2.2: 2 h / 20 °C
3.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction
4.1: ammonia / ethylene glycol / 6.92 h / 25 - 65 °C
View Scheme
参考文献
Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045
反应条件
1.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction
2.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction
2.2: 2 h / 20 °C
3.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction
4.1: ammonia; water / 5 h / 60 °C / 1034.32 Torr
View Scheme
参考文献
Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045
反应条件
zinc in acetic acid
1.) 15 deg C, 1.5 h; 2.) rooom temperature, 6 h;
参考文献
Daisley, Roy W.; Hanbali, Jafar R.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 999 - 1001
反应条件
1: sulfuric acid / Heating
2: UHP; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Zhang, Fang; Duan, Xin-Fang
Organic Letters, 2011 , vol. 13, # 22 p. 6102 - 6105
