4-甲氧基-2-吡啶甲醇 1-氧化物合成路线 （共 7 条）
反应条件
sodium tetrahydroborate
T=0 - 5°C; 0.666667 h;
参考文献
Mizuno, Yoshihisa; Endo, Takeshi; Takahashi, Akira; Inaki, Atsuko
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3041 - 3048
反应条件
in methanol
16 h; Ambient temperature;
参考文献
Mizuno, Yoshihisa; Endo, Takeshi; Takahashi, Akira; Inaki, Atsuko
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3041 - 3048
反应条件
1: nitric acid / 8 h / 80 °C / |Large scale
2: sodium methylate / 8 h / 20 °C / |Large scale
3: acetic acid / 90 - 100 °C / |Large scale
4: acetic anhydride; dihydrogen peroxide / water / 14 h / 0 - 45 °C
View Scheme
参考文献
Rejman, Dominik; Erbs, Jiri; Rosenberg, Ivan
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 473 - 476
反应条件
1: sodium methylate / 8 h / 20 °C / |Large scale
2: acetic acid / 90 - 100 °C / |Large scale
3: acetic anhydride; dihydrogen peroxide / water / 14 h / 0 - 45 °C
View Scheme
参考文献
Rejman, Dominik; Erbs, Jiri; Rosenberg, Ivan
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 473 - 476
反应条件
1: 74.6 percent / NaBH4 / 0.67 h / 0 - 5 °C
2: 74.4 percent / methanol / 16 h / Ambient temperature
View Scheme
参考文献
Mizuno, Yoshihisa; Endo, Takeshi; Takahashi, Akira; Inaki, Atsuko
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3041 - 3048
反应条件
1: 9.85 g / methanol / 0.33 h / 60 °C
2: 6.6 g / 20percent HCl / 0.5 h / 110 °C
3: 78 percent / NaBH4 / 0.67 h / 0 - 5 °C
View Scheme
参考文献
Mizuno, Yoshihisa; Endo, Takeshi; Takahashi, Akira; Inaki, Atsuko
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3041 - 3048
反应条件
1: 6.6 g / 20percent HCl / 0.5 h / 110 °C
2: 78 percent / NaBH4 / 0.67 h / 0 - 5 °C
View Scheme
参考文献
Mizuno, Yoshihisa; Endo, Takeshi; Takahashi, Akira; Inaki, Atsuko
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 10 p. 3041 - 3048
