1-[3-(二甲基氨基)丙基]-1-(4-氟苯基)-1,3-二氢-5-异苯并呋喃甲酰胺合成路线 （共 6 条）
反应条件
trichlorophosphate in acetonitrile T=60°C; Heating / reflux;
参考文献
Greenwood, Alan Kenneth; McHattie, Derek; Rechka, Josef A.; Hedger, Paul C.M.; Gamble, Mark P.
Patent: US2004/14997 A1, 2004 ;
Location in patent: Page 11 ;
反应条件
potassium hydroxide in tert-butyl alcohol
T=75 - 80°C; 1 h; Purification / work up;
参考文献
Sathyanarayana, Swargam; Kumar, Yatendra; Sharma, Tarum Kant; Biswas, Sujay; Vijayraghavan, Bakthavthsalan
Patent: US2004/254385 A1, 2004 ;
Location in patent: Page 3 ;
反应条件
dihydrogen peroxide; potassium hydroxide in ethanol; dimethyl sulfoxide
T=60°C; 2 h;
参考文献
Banala, Ashwini K.; Zhang, Peng; Plenge, Per; Cyriac, George; Kopajtic, Theresa; Katz, Jonathan L.; Loland, Claus Juul; Newman, Amy Hauck
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9709 - 9724
反应条件
1: With phosphoric acid in water
T=105°C; 14 h;
2: With ammonia in water
pH=8 - 10; Purification / work up;
参考文献
MEDITAB SPECIALITIES PVT. LTD; WAIN, Christopher, Paul
Patent: WO2005/12278 A2, 2005 ;
Location in patent: Page/Page column 10-11 ;
反应条件
water; sodium hydroxide
T=85°C; 4 h;
参考文献
Sharma, Manav; Jawa, Parikshit R.; Gill, Ravinder S.; Bansal, Gulshan
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 5 p. 836 - 848
反应条件
water; sodium hydroxide
384 h; Photolysis;
参考文献
Sharma, Manav; Jawa, Parikshit R.; Gill, Ravinder S.; Bansal, Gulshan
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 5 p. 836 - 848
