2-(3-氯苯基)-1,3-二氧戊环合成路线 （共 8 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere 1.2: -78 - -20 °C / Inert atmosphere 2.1: hydrogenchloride / tetrahydrofuran; water / 4 h / Reflux View Scheme
参考文献
Aksjonova, Kristine; Belyakov, Sergey; Liepinsh, Edvards; Boman, Arne; Lundstedt, Torbjorn; Lek, Per; Trapencieris, Peteris
Synthesis (Germany), 2012 , vol. 44, # 14 art. no. SS-2012-N0094-OP, p. 2200 - 2208
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI 1.) benzene/THF, 63 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4844 - 4848
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI 1.) benzene/THF, 63 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4844 - 4848
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI 1.) benzene/THF, 63 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4844 - 4848
反应条件
NaH-t-AmONa-Ni(OAc)2-bpy-KI 1.) benzene/THF, 63 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Lourak, Mouhsine; Vanderesse, Regis; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4844 - 4848
反应条件
toluene-4-sulfonic acid in benzene
12 h; Heating;
参考文献
Huerta, Fernando F.; Gomez, Cecilia; Yus, Miguel
Tetrahedron, 1999 , vol. 55, # 13 p. 4043 - 4050
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=-60°C; 1.5 h;
参考文献
Barbasiewicz, Michal; Makosza, Mieczyslaw
Organic Letters, 2006 , vol. 8, # 17 p. 3745 - 3748
参考文献
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT
Patent: US4304938 A1, 1981 ;
