5-甲氧基-2-氨基苯甲醛乙烯乙缩醛合成路线 （共 4 条）
反应条件
1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C 2: hydrogenchloride; water / acetone / 2 h / 20 °C 3: ammonia / 5 h / 130 °C / Cooling with acetone-dry ice 4: trichlorophosphate / 4 h / 95 - 100 °C / Reflux View Scheme
参考文献
Ramurthy, Savithri; Costales, Abran; Jansen, Johanna M.; Levine, Barry; Renhowe, Paul A.; Shafer, Cynthia M.; Subramanian, Sharadha
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1678 - 1681
反应条件
hydrogen; sodium acetate; platinum(IV) oxide in ethyl acetate
P=3345.86 Torr; 16 h;
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: 92 percent / p-toluenesul;fonic acid / toluene / 6 h / Heating
2: 89 percent / sodium sulfide / ethanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Wani; Ronman; Lindley; Wall
Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 554 - 560
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: toluene-4-sulfonic acid / toluene / 100 °C
3: platinum(IV) oxide; hydrogen; sodium acetate / ethyl acetate / 20 °C
View Scheme
参考文献
Ramurthy, Savithri; Costales, Abran; Jansen, Johanna M.; Levine, Barry; Renhowe, Paul A.; Shafer, Cynthia M.; Subramanian, Sharadha
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1678 - 1681
